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Publications of year 2005 |
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Stanislas Dehaene,
Jean-René Duhamel,
Marc D. Hauser,
and Giacomo Rizzolatti.
From Monkey Brain to Human Brain. A Fyssen Foundation Symposium.
MIT Press,
2005.
[PDF] [bibtex-entry]
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Claire Sergent.
Dynamique de l'accès à la conscience : caractérisation comportementale et bases neurales de l'accès à la conscience lors du clignement attentionnel (attentional blink).
Thesis/Dissertation,
Université Paris XI,
2005.
Note: Supervised by Stanislas Dehaene.
[bibtex-entry]
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Valérie Ventureyra.
À la recherche de la langue perdue: étude psycholinguistique de l'attrition de la première langue chez des cor'eens adoptés en France.
Thesis/Dissertation,
école des hautes études en sciences sociales,
Paris,
January 2005.
Note: Supervised by Christophe Pallier.
[PDF]
Abstract: |
L'exposition à une langue pendant l'enfance laisse-t-elle des traces indélébiles dans le cerveau ? Est-ce possible qu'une seconde langue (L2) "remplace" une première langue (L1), dans des circonstances particulières ? L'hypothèse de la période critique pour l'acquisition du langage prédit que les aires langagières du cerveau perdent la plasticité avec l'âge. Une conséquence de cette hypothèse est donc que l'exposition à une langue donnée pendant les premières années de vie laissera des traces permanentes dans le cerveau. Ceci implique que la perte complète d'une langue maternelle ne pourrait avoir lieu. L'autre conséquence de la perte de plasticité est la difficulté croissante en fonction de l'âge de l'apprenant. Des études de l'acquisition d'une deuxième langue et des cas de personnes privées de langage pendant les premières années de vie (les "enfants-loups" et parfois les sourds nés dans des familles d' entendants) portent des preuves en faveur de la perte de plasticité. Dans cette thèse nous explorons les traces éventuelles de la L1 apprise et `perdue'pendant l'enfance, et la compétence dans la L2 apprise plus tard dans l'enfance. Nous avons choisi d'étudier des adoptés d'origine étrangère pour examiner ces questions. Notre étude concerne des adultes d'origine coréenne adoptés par des familles francophones entre l'âge de 3 et 10 ans et ayant été complètement isolés de leur langue et culture d'origine depuis leur arrivé en France il y a 15 à 30 ans. Cette thèse comporte trois parties : 1.) la recherche de traces de mémoire linguistique et autres (reconnaissance de séries numériques, de mots, de séries de jours de la semaine, de morphologie faciale) ; 2.) la recherche de traces éventuelles de la phonologie du coréen (discrimination de phonèmes, entra?nement aux sons du coréen) et 3.) l'évaluation de certains aspects du français (genre grammatical , phonotactique). Nous avons comparé les résultats des adoptés à ceux de francophones sans connaissances du coréen dans chaque expérience, et à ceux de Coréens natifs résidant en France pour certaines expériences. Les expériences de mémoire ont révélé l'existence de très peu de traces du coréen et d'autres types de souvenirs. De la même façon, les expériences de phonologie du coréen ont montré un comportement similaire à celui des francophones, et ceci indépendamment de la réexposition de certains adoptés à la langue coréenne lors de séjours de courte durée en Corée. Ces résultats nous suggèrent soit une perte du coréen, soit une inaccessibilité importante à cette langue par les adoptés. Les performances des adoptés sur les tests de français sont également semblables à celles des francophones et diffèrent de celle des Coréens natifs, indiquant une bonne ma?trise des aspects du français difficiles pour des Coréens. L'ensemble des données montre que les adoptés coréens sont devenus comme des francophones natifs dans leur traitement langagier. L'important rôle joué par la plasticité du système langagier chez les adoptés est corroboré par nos résultats, qui suggèrent qu'une langue maternelle peut être facilement remplacée par une autre langue pendant l'enfance. Il y a une convergence entre nos résultats et ceux d'études de cas d'attrition langagière chez des jeunes enfants adoptés montrant que la L1 est rapidement oubliée (Nicoladis \& Grabois, 2002 ; Isurin, 2000), alors que la L2 est vite assimilée |
[bibtex-entry]
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Stanislas Dehaene.
Imaging conscious and subliminal word processing.
In E. Awh & S. Keele U Mayr, editor,Developing individuality in the human brain : A tribute to Michael Posner,
pages 65-86.
American Psychological Association,
2005.
[PDF] [bibtex-entry]
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Stanislas Dehaene.
Evolution of human cortical circuits for reading and arithmetic: The neuronal recycling hypothesis.
In Stanislas Dehaene,
Jean-René Duhamel,
Marc D. Hauser,
and Giacomo Rizzolatti, editors,From Monkey Brain to Human Brain. A Fyssen Foundation Symposium,
chapter 8,
pages 133-157.
MIT Press,
2005.
[PDF] [bibtex-entry]
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Stanislas Dehaene and Jean-Pierre Changeux.
Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness.
PLoS Biol,
3(5):e141,
May 2005.
[WWW] [PDF]
Abstract: |
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood. We use computer simulations to explore the conditions under which spontaneous activity emerges from a simplified model of multiple interconnected thalamocortical columns linked by long-range, top-down excitatory axons, and to examine its interactions with stimulus-induced activation. Simulations help characterize two main states of activity. First, spontaneous gamma-band oscillations emerge at a precise threshold controlled by ascending neuromodulator systems. Second, within a spontaneously active network, we observe the sudden "ignition" of one out of many possible coherent states of high-level activity amidst cortical neurons with long-distance projections. During such an ignited state, spontaneous activity can block external sensory processing. We relate those properties to experimental observations on the neural bases of endogenous states of consciousness, and particularly the blocking of access to consciousness that occurs in the psychophysical phenomenon of "inattentional blindness," in which normal subjects intensely engaged in mental activity fail to notice salient but irrelevant sensory stimuli. Although highly simplified, the generic properties of a minimal network may help clarify some of the basic cerebral phenomena underlying the autonomy of consciousness |
[bibtex-entry]
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Stanislas Dehaene,
Laurent Cohen,
Mariano Sigman,
and Fabien Vinckier.
The neural code for written words: a proposal.
Trends Cogn Sci,
9:335-341,
2005.
[WWW] [PDF]
Abstract: |
How is reading, a cultural invention, coded by neural populations in the human brain? The neural code for written words must be abstract, because we can recognize words regardless of their location, font and size. Yet it must also be exquisitely sensitive to letter identity and letter order. Most existing coding schemes are insufficiently invariant or incompatible with the constraints of the visual system. We propose a tentative neuronal model according to which part of the occipito-temporal 'what' pathway is tuned to writing and forms a hierarchy of local combination detectors sensitive to increasingly larger fragments of words. Our proposal can explain why the detection of 'open bigrams' (ordered pairs of letters) constitutes an important stage in visual word recognition |
[bibtex-entry]
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Ghislaine Dehaene-Lambertz,
Christophe Pallier,
Willy Serniclaes,
Liliane Sprenger-Charolles,
Antoinette Jobert,
and Stanislas Dehaene.
Neural correlates of switching from auditory to speech perception.
Neuroimage,
24(1):21--33,
January 2005.
[WWW] [PDF]
Abstract: |
Many people exposed to sinewave analogues of speech first report hearing them as electronic glissando and, later, when they switch into a 'speech mode', hearing them as syllables. This perceptual switch modifies their discrimination abilities, enhancing perception of differences that cross phonemic boundaries while diminishing perception of differences within phonemic categories. Using high-density evoked potentials and fMRI in a discrimination paradigm, we studied the changes in brain activity that are related to this change in perception. With ERPs, we observed that phonemic coding is faster than acoustic coding: The electrophysiological mismatch response (MMR) occurred earlier for a phonemic change than for an equivalent acoustic change. The MMR topography was also more asymmetric for a phonemic change than for an acoustic change. In fMRI, activations were also significantly asymmetric, favoring the left hemisphere in both perception modes. Furthermore, switching to the speech mode significantly enhanced activation in the posterior parts of the left superior gyrus and sulcus relative to the non-speech mode. When responses to a change of stimulus were studied, a cluster of voxels in the supramarginal gyrus was activated significantly more by a phonemic change than by an acoustic change. These results demonstrate that phoneme perception in adults relies on a specific and highly efficient left-hemispheric network, which can be activated in top-down fashion when processing ambiguous speech/non-speech stimuli |
[bibtex-entry]
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Silke Dodel,
Narly Golestani,
Christophe Pallier,
Vincent Elkouby,
Denis Le Bihan,
and Jean-Baptiste Poline.
Condition-dependent functional connectivity: syntax networks in bilinguals.
Philos Trans R Soc Lond B Biol Sci,
360(1457):921--935,
May 2005.
[WWW] [PDF]
Abstract: |
This paper introduces a method to study the variation of brain functional connectivity networks with respect to experimental conditions in fMRI data. It is related to the psychophysiological interaction technique introduced by Friston et al. and extends to networks of correlation modulation (CM networks). Extended networks containing several dozens of nodes are determined in which the links correspond to consistent correlation modulation across subjects. In addition, we assess inter-subject variability and determine networks in which the condition-dependent functional interactions can be explained by a subject-dependent variable. We applied the technique to data from a study on syntactical production in bilinguals and analysed functional interactions differentially across tasks (word reading or sentence production) and across languages. We find an extended network of consistent functional interaction modulation across tasks, whereas the network comparing languages shows fewer links. Interestingly, there is evidence for a specific network in which the differences in functional interaction across subjects can be explained by differences in the subjects' syntactical proficiency. Specifically, we find that regions, including ones that have previously been shown to be involved in syntax and in language production, such as the left inferior frontal gyrus, putamen, insula, precentral gyrus, as well as the supplementary motor area, are more functionally linked during sentence production in the second, compared with the first, language in syntactically more proficient bilinguals than in syntactically less proficient ones. Our approach extends conventional activation analyses to the notion of networks, emphasizing functional interactions between regions independently of whether or not they are activated. On the one hand, it gives rise to testable hypotheses and allows an interpretation of the results in terms of the previous literature, and on the other hand, it provides a basis for studying the structure of functional interactions as a whole, and hence represents a further step towards the notion of large-scale networks in functional imaging |
[bibtex-entry]
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Jessica Dubois,
Franck Lethimonnier,
Francoise Vaufrey,
Philippe Robert,
and Denis Le Bihan.
Frequency-shift based detection of BMS contrast agents using SSFP: potential for MRA..
Magn Reson Imaging,
23(3):453--462,
April 2005.
[WWW] [PDF]
Abstract: |
A novel mechanism of MRI contrast enhancement, based on the detection by a balanced steady-state free precession (SSFP) sequence of the proton resonance frequency shift induced by bulk magnetic susceptibility (BMS) contrast agents, was investigated. The potential for this contrast mechanism to image blood vessels was explored. The relaxation time and the frequency shift effects of gadolinium- and dysprosium-DOTA on SSFP signal was first simulated and evaluated on a water phantom at 1.5 T. In vitro, a 5-mM concentration in contrast agent induced a 20-Hz frequency shift, leading to a signal increase of 92\% for Dy-DOTA, and a 10-Hz frequency shift, leading to a signal increase of 58\% for Gd-DOTA at the reference frequency, taking into account the nonlinear SSFP signal response on frequency offset. The concept was then evaluated in vivo on anesthetized rabbits. Low doses of dysprosium-DOTA were injected in their vascular system, and imaging was performed at the level of neck vessels. Following a bolus injection, mean signal changes of 31\%, 20\% and 14\% were observed in the carotid arteries, the vertebral veins and the jugular veins, respectively. The bolus peak times in arteries and veins were consistent with the rabbit vascular circulation. This frequency-shift based contrast mechanism presents interesting potential for contrast-enhanced MR angiography (CE-MRA) compared to usual relaxation-based contrast, but further investigations on reproducibility will be necessary. |
[bibtex-entry]
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Teodora Gliga and Ghislaine Dehaene-Lambertz.
Structural encoding of body and face in human infants and adults.
J Cogn Neurosci,
17(8):1328--1340,
August 2005.
[WWW] [PDF]
Abstract: |
Most studies on visual perception of human beings have focused on perception of faces. However, bodies are another important visual element, which help us to identify a member of our species in the visual scene. In order to study whether similar configural information processing is used in body and face perception, we recorded high-density even-related potentials (ERPs) to normal and distorted faces and bodies in adults and 3-month-old infants. In adults, the N1 responses evoked by bodies and faces were similar in amplitude but differed slightly in latency. The voltage topography of N1 also differed in concordance with fMRI data showing that two distinct areas are involved in face and body perception. Distortion affected ERPs to faces and bodies similarly from N1 on, although the effect was significant earlier for bodies than for faces. These results suggest that fast processing of configural information is not specific to faces but it also occurs for bodies. In 3-month-old infants, distortion decreased the amplitude of P400 around 450 msec, showing no interaction with image category. This result demonstrates that infants are not only able to recognize the normal configuration of faces, but also that of bodies. This could either be related to an innate knowledge of this particular type of biological object, or to fast learning through intense exposure during the first months of life |
[bibtex-entry]
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Carole Henry,
Raphaël Gaillard,
Emmanuelle Volle,
Jacques Chiras,
Sophie Ferrieux,
Stanislas Dehaene,
and Laurent Cohen.
Brain activations during letter-by-letter reading: A follow-up study.
Neuropsychologia,
May 2005.
[WWW] [PDF]
Abstract: |
Lesions affecting the ventral cortex of the left temporal lobe commonly yield a selective reading impairment known as pure alexia. It is thought to result from the disruption or deafferentation of the Visual Word Form Area (VWFA), a region in the left lateral occipitotemporal sulcus activated whenever normal subjects are viewing alphabetic strings. Most pure alexic patients retain the ability to identify single letters, and develop a strategy of letter-by-letter (LBL) reading. We recently studied fMRI activations in LBL readers and clarified the underlying mechanisms. However, LBL reading is a dynamic process which may improve over months or years of practice, although the cerebral bases of this continuing improvement are currently unknown. We had the opportunity to run the same behavioural testing and fMRI experiment a second time in an alexic patient, 8 months after collecting the data reported by Cohen et al. [Cohen, L., Henry, C., Dehaene, S., Molko, N., Lehericy, S., Martinaud, O., Lemer, C., & Ferrieux, S. (2004). The pathophysiology of letter-by-letter reading. Neuropsychologia, 42, 1768-1780]. We analyze the changes that occurred over this period in the pattern of reading-related activations, while the patient's LBL reading improved. The activation level decreased in most of the overall network between the two sessions. This general trend contrasted with a focal increase restricted to specific left frontal and parietal areas. When studying the contrast between words and consonant strings, which may be taken as a correlate of LBL reading, we also found a general decrease, except for similar left frontal and parietal regions, which showed a significant increase. We suggest that the pattern of evolution fits with the minimal hypothesis of normal strategic abilities and skill learning, associated with perceptual tuning in right-hemispheric structures able to substitute the disrupted VWFA |
[bibtex-entry]
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Edward M Hubbard,
Manuela Piazza,
Philippe Pinel,
and Stanislas Dehaene.
Interactions between number and space in parietal cortex.
Nat Rev Neurosci,
6(6):435-48,
June 2005.
[WWW] [PDF]
Abstract: |
Since the time of Pythagoras, numerical and spatial representations have been inextricably linked. We suggest that the relationship between the two is deeply rooted in the brain's organization for these capacities. Many behavioural and patient studies have shown that numerical-spatial interactions run far deeper than simply cultural constructions, and, instead, influence behaviour at several levels. By combining two previously independent lines of research, neuroimaging studies of numerical cognition in humans, and physiological studies of spatial cognition in monkeys, we propose that these numerical-spatial interactions arise from common parietal circuits for attention to external space and internal representations of numbers |
[bibtex-entry]
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Lionel Naccache.
Visual phenomenal consciousness: a neurological guided tour..
Prog Brain Res,
150:185-95,
2005.
[PDF] [bibtex-entry]
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Lionel Naccache,
Stanislas Dehaene,
Laurent Cohen,
Marie-Odile Habert,
Elodie Guichart-Gomez,
Damien Galanaud,
and Jean-Claude Willer.
Effortless control: executive attention and conscious feeling of mental effort are dissociable.
Neuropsychologia,
43(9):1318-1328,
2005.
[WWW] [PDF]
Abstract: |
Recruitment of executive attention is normally associated to a subjective feeling of mental effort. Here we investigate the nature of this coupling in a patient with a left mesio-frontal cortex lesion including the anterior cingulate cortex (ACC), and in a group of comparison subjects using a Stroop paradigm. We show that in normal subjects, subjective increases in effort associated with executive control correlate with higher skin-conductance responses (SCRs). However, our patient experienced no conscious feeling of mental effort and showed no SCR, in spite of exhibiting normal executive control, and residual right anterior cingulate activity measured with event-related potentials (ERPs). Finally, this patient demonstrated a pattern of impaired behavior and SCRs in the Iowa gambling task-elaborated by Damasio, Bechara and colleagues-replicating the findings reported by these authors for other patients with mesio-frontal lesions. Taken together, these results call for a theoretical refinement by revealing a decoupling between conscious cognitive control and consciously reportable feelings. Moreover, they reveal a fundamental distinction, observed here within the same patient, between the cognitive operations which are depending on normal somatic marker processing, and those which are withstanding to impairments of this system |
[bibtex-entry]
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Lionel Naccache,
Raphaël Gaillard,
Claude Adam,
Dominique Hasboun,
Stéphane Clémenceau,
Michel Baulac,
Stanislas Dehaene,
and Laurent Cohen.
A direct intracranial record of emotions evoked by subliminal words.
Proc Natl Acad Sci U S A,
102(21):7713-7,
May 2005.
[WWW] [PDF]
Abstract: |
A classical but still open issue in cognitive psychology concerns the depth of subliminal processing. Can the meaning of undetected words be accessed in the absence of consciousness? Subliminal priming experiments in normal subjects have revealed only small effects whose interpretation remains controversial. Here, we provide a direct demonstration of semantic access for unseen masked words. In three epileptic patients with intracranial electrodes, we recorded brain potentials from the amygdala, a neural structure that responds to fearful or threatening stimuli presented in various modalities, including written words. We show that the subliminal presentation of emotional words modulates the activity of the amygdala at a long latency (>800 ms). Our result indicates that subliminal words can trigger long-lasting cerebral processes, including semantic access to emotional valence |
[bibtex-entry]
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L. Naccache,
M. Habert,
Z. Malek,
L. Cohen,
and J-C. Willer.
Activation of secondary auditory cortex in a deaf patient during song hallucinosis.
J Neurol,
252(6):738-739,
June 2005.
[WWW] [bibtex-entry]
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Lionel Naccache,
Louis Puybasset,
Raphaël Gaillard,
Emilie Serve,
and Jean-Claude Willer.
Auditory mismatch negativity is a good predictor of awakening in comatose patients: a fast and reliable procedure.
Clin Neurophysiol,
116(4):988-9,
April 2005.
[WWW] [PDF] [bibtex-entry]
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Kimihiro Nakamura,
Stanislas Dehaene,
Antoinette Jobert,
Denis Le Bihan,
and Sid Kouider.
Subliminal convergence of kanji and kana words: further evidence for functional parcellation of the posterior temporal cortex in visual word perception.
J Cogn Neurosci,
17(6):954-68,
June 2005.
[WWW] [PDF]
Abstract: |
Recent evidence has suggested that the human occipitotemporal region comprises several subregions, each sensitive to a distinct processing level of visual words. To further explore the functional architecture of visual word recognition, we employed a subliminal priming method with functional magnetic resonance imaging (fMRI) during semantic judgments of words presented in two different Japanese scripts, Kanji and Kana. Each target word was preceded by a subliminal presentation of either the same or a different word, and in the same or a different script. Behaviorally, word repetition produced significant priming regardless of whether the words were presented in the same or different script. At the neural level, this cross-script priming was associated with repetition suppression in the left inferior temporal cortex anterior and dorsal to the visual word form area hypothesized for alphabetical writing systems, suggesting that cross-script convergence occurred at a semantic level. fMRI also evidenced a shared visual occipito-temporal activation for words in the two scripts, with slightly more mesial and right-predominant activation for Kanji and with greater occipital activation for Kana. These results thus allow us to separate script-specific and script-independent regions in the posterior temporal lobe, while demonstrating that both can be activated subliminally |
[bibtex-entry]
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Sandy Sangrigoli,
Christophe Pallier,
Anne-Marie Argenti,
Valérie Ventureyra,
and Scania de Schonen.
Reversibility of the other-race effect in face recognition during childhood.
Psychol Sci,
16(6):440-4,
June 2005.
[WWW] [PDF]
Abstract: |
Abstract-Early experience with faces of a given racial type facilitates visual recognition for this type of face relative to others. To assess whether this so-called other-race effect can be reversed by subsequent experience with new types of faces, we tested adults of Korean origin who were adopted by European Caucasian families when they were between the ages of 3 to 9. The adoptees performed a face recognition task with photographs of Caucasian and Asian faces. They performed exactly like a control group of French participants, identifying the Caucasian faces better than the Asiatic ones. In contrast, a control group of Koreans showed the reverse pattern. This result indicates that the face recognition system remains plastic enough during childhood to reverse the other-race effect |
[bibtex-entry]
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Claire Sergent,
Sylvain Baillet,
and Stanislas Dehaene.
Timing of the brain events underlying access to consciousness during the attentional blink.
Nat Neurosci,
September 2005.
[WWW] [PDF]
Abstract: |
In the phenomenon of attentional blink, identical visual stimuli are sometimes fully perceived and sometimes not detected at all. This phenomenon thus provides an optimal situation to study the fate of stimuli not consciously perceived and the differences between conscious and nonconscious processing. We correlated behavioral visibility ratings and recordings of event-related potentials to study the temporal dynamics of access to consciousness. Intact early potentials (P1 and N1) were evoked by unseen words, suggesting that these brain events are not the primary correlates of conscious perception. However, we observed a rapid divergence around 270 ms, after which several brain events were evoked solely by seen words. Thus, we suggest that the transition toward access to consciousness relates to the optional triggering of a late wave of activation that spreads through a distributed network of cortical association areas |
[bibtex-entry]
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Mariano Sigman and Stanislas Dehaene.
Parsing a cognitive task: a characterization of the mind's bottleneck.
PLoS Biol,
3(2):e37,
February 2005.
[WWW] [PDF]
Abstract: |
Parsing a mental operation into components, characterizing the parallel or serial nature of this flow, and understanding what each process ultimately contributes to response time are fundamental questions in cognitive neuroscience. Here we show how a simple theoretical model leads to an extended set of predictions concerning the distribution of response time and its alteration by simultaneous performance of another task. The model provides a synthesis of psychological refractory period and random-walk models of response time. It merely assumes that a task consists of three consecutive stages-perception, decision based on noisy integration of evidence, and response-and that the perceptual and motor stages can operate simultaneously with stages of another task, while the central decision process constitutes a bottleneck. We designed a number-comparison task that provided a thorough test of the model by allowing independent variations in number notation, numerical distance, response complexity, and temporal asynchrony relative to an interfering probe task of tone discrimination. The results revealed a parsing of the comparison task in which each variable affects only one stage. Numerical distance affects the integration process, which is the only step that cannot proceed in parallel and has a major contribution to response time variability. The other stages, mapping the numeral to an internal quantity and executing the motor response, can be carried out in parallel with another task. Changing the duration of these processes has no significant effect on the variance |
[bibtex-entry]
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Mariano Sigman,
Hong Pan,
Yihong Yan,
Emily Stern,
David Silbersweig,
and Charles Gilbert.
Top-Down reorganization of activity in the visual pathway after learning a shape identification task.
Neuron,
46(5):823-835,
2005.
[PDF] [bibtex-entry]
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Armelle Viard,
Martine F Flament,
Eric Artiges,
Stanislas Dehaene,
Lionel Naccache,
David Cohen,
Philippe Mazet,
Marie-Christine Mouren,
and Jean-Luc Martinot.
Cognitive control in childhood-onset obsessive-compulsive disorder: a functional MRI study.
Psychol Med,
35(7):1007--1017,
July 2005.
[PDF]
Abstract: |
BACKGROUND: Failure to resist chronic obsessive-compulsive symptoms may denote an altered state of cognitive control. We searched for the cerebral regions engaged in this dysfunction. METHOD: Differences in brain regional activity were examined by event-related functional magnetic regional imaging (fMRI) in a group of adolescents or young adults (n = 12) with childhood-onset obsessive-compulsive disorder (OCD), relative to healthy subjects. Subjects performed a conflict task involving the presentation of two consecutive and possibly conflicting prime and target numbers. Patients' image dataset was further analysed according to resistance or non-resistance to symptoms during the scans. RESULTS: Using volume correction based on a priori hypotheses, an exploratory analysis revealed that, within the prime-target repetition condition, the OCD subjects activated more than healthy subjects a subregion of the anterior cingulate gyrus and the left parietal lobe. Furthermore, compared with 'resistant' patients, the 'non-resistant' OCD subjects activated a bilateral network including the precuneus, pulvinar and paracentral lobules. CONCLUSIONS: Higher regional activations suggest an abnormal amplification process in OCD subjects during the discrimination of repetitive visual stimuli. The regional distribution of functional changes may vary with the patients' ability to resist obsessions |
[bibtex-entry]
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Fabien Vinckier.
Etudes en psychophysique, psychologie et imagerie cerebrale fonctionnelle.
Master's thesis,
2005.
[PDF] [bibtex-entry]
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Stanislas Dehaene.
Les bases biologiques de l arithmétique élémentaire.
Pour la Science,
Avril 2005.
[PDF] [bibtex-entry]
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Stanislas Dehaene.
Foreword: Consciousness and Cautiousness. , vol. 150, pp ix-x, 2005..
Progress in Brain Research,
2005.
[PDF] [bibtex-entry]
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Nicolas Molko,
Anna Wilson,
and Stanislas Dehaene.
La dyscalculie développementale, un trouble primaire de la perception des nombres.
Médecine & Enfance,
Mars 2005.
[PDF] [bibtex-entry]
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Stanislas Dehaene,
Véronique Izard,
and Manuela Piazza.
Control over non-numerical parameters in numerosity experiments.
Note: Unpublished,
2005.
[PDF] [bibtex-entry]
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